Study Reveals Air Pollution May Increase Lupus Risk by Up to 27%: Discoveries from 459,815 Participants

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Researchers discovered that greater adjusted hazard ratios for incident SLE are associated with every interquartile range rise in air pollution levels, based on an analysis of data spanning 459,815 individuals

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According to the study, the biggest harm is to people who have both a high genetic risk and a high level of air pollution exposure; for NO2 exposure, the hazard ratio rises to 5.61.

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Huazhong University researchers have found a remarkable way in which air pollution, especially nitrogen dioxide, and genetic risk combine to increase the likelihood of developing lupus

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Even though there were only 399 occurrences of SLE out of around 460,000 people, the results highlight the urgent need for more cohort studies to investigate these connections

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Yaohua Tian, a coauthor, highlights how this research should guide more stringent air quality standards that aim to lessen the incidence of lupus and reduce exposure to dangerous pollutants.

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According to Jian Yang's findings, people who were genetically predisposed to lupus had a twofold increased chance of getting the disease, even in the case of very little pollution exposure

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Remarkably, the study pointed out that because of the different environmental conditions in Europe, where air pollution levels are often lower, it is still important to assess this link.

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This study emphasises the significance of looking at long-term air pollution exposure and new-onset lupus, whereas prior studies concentrated on short-term exposure and disease activity

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