Spravato Nasal Spray Approved for Solo Use in Depression Treatment

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FDA cleared Spravato nasal spray as a standalone depression treatment, eliminating the need for combining it with daily antidepressant pills.

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The nasal spray offers relief to one-third of 21 million Americans with severe depression who don't respond to standard antidepressant pills.

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Spravato works differently from traditional antidepressants targeting serotonin, though its exact antidepressant mechanism remains unknown.

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Patients must receive treatment at 3,000 certified clinics across the U.S., with mandatory two-hour monitoring due to potential side effects.

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Phase four trial showed improved depressive symptoms beginning about 24 hours after treatment, lasting through at least one month.

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Over 140,000 patients worldwide have used Spravato since its 2019 launch, with more than a fifth achieving remission.

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Sales reached $780 million in nine months of 2024, with Johnson & Johnson projecting annual revenue between $1-5 billion.

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Dr. Mattingly's St. Louis clinic treated 6,000 patients, with people starting to feel somewhat better within same day or next day.

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The spray cannot be picked up at pharmacies and requires strict medical supervision due to risks of dissociation and drowsiness.

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Patients now have flexibility to choose between spray-only treatment or combination therapy based on individual needs.

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