Psilocybin Mushroom Extract Shows 19% Reduction in OCD Behaviors in Mice: Hebrew University Study Highlights Potential
Karmactive Staff
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According to the study, grooming habits were decreased by 19.20% by mushroom extract and 14.60% by psilocybin.
SAPAP3 knockout mice, which were genetically altered to display anxiety and excessive grooming, were used in the study.
Psilocybin's potential as an alternative is shown by the fact that 40% of OCD patients do not respond well to conventional treatments.
According to safety results, the psilocybin and control groups had some skin lesions, whereas the mushroom extract group had none.
The mice used in the study received a dosage of 4.4 mg/kg, which is about 25 mg for people.
Marble burying, open field, and elevated plus maze tests were among the behavioral evaluations used to gauge anxiety and obsessive tendencies.
Fronto-striatal circuits and glutamatergic pathways may be involved in psilocybin's therapeutic effects.
The study adds to an expanding collection of data on psychedelics and mental health, which includes earlier studies on body dysmorphic disorder and OCD.